BELL WORK:
What do you think of when you
hear the word mutation?
What do you think of when you
hear the word mutation?
Essential Question:
What are the types of DNA mutations, and what effect
do they have on transcription/translation?
Instructional Focus / TLW:
Explain how DNA mutations modify proteins.
BEFORE WE MOVE ON....
THINGS WE ALREADY KNOW THAT WILL HELP...
In DNA: Replication
A-T-C-G
T-A-G-C
DNA TO mRNA: Transcription
A-T-C-G Use codon wheel.
U-A-G-C RNA HAS "U" NOT "T"
mRNA TO tRNA: Translation /polypeptide
U-A-G-C
A-U-C-G
MUTATION FACTS:
1. A mutation is a change that occurs in our DNA sequence.
2. Mutations can occur during DNA replication.
3. There are several types of DNA mutations.
4. DNA mutations may or may not cause a problem.
We will investigate several
types of DNA Mutations:
1. Point
2. Substitution
3. Inversion
4. Insertion / Frameshift
5. Deletion / Frameshift
* And later analyze for missense and nonsense mutations...
missense = a change in one amino acid in a protein
nonsense = codon is changed to a premature stop
/
Instructional Focus / TLW:
Explain how DNA mutations modify proteins.
1. Complete the POINT mutation handout. USE A CODON WHEEL.
We will compare lines 2, 3, 4, 5, 6, and 7 to line 1.
Line one is the "NORMAL" DNA.
Instructional Focus / TLW:
Explain how DNA mutations modify proteins.
1. Complete the POINT mutation handout. USE A CODON WHEEL.
We will compare lines 2, 3, 4, 5, 6, and 7 to line 1.
Line one is the "NORMAL" DNA.
Instructional Focus / TLW:
Explain how DNA mutations modify proteins.
1. Complete the SUBSTITUTION mutation handout. USE A CODON WHEEL.
We will compare lines 2, 3, 4, 5, 6, and 7 to line 1.
Line one is the "NORMAL" DNA.
THE ONLY THING YOU TURN IN TODAY IS THE TICKET / QUIZ.
HIGH-QUALITY COMPLETE ANSWERS ARE EXPECTED.
TICKET / QUIZ:
1. List 3 things that you learned today.
2. Explain or draw: How to recognize a point mutation?
3. Explain or draw: How to recognize a substitution mutation?
4. Explain how DNA mutations modify proteins.
TURN IN TICKET-QUIZ---GREEN CONTAINER-TOP OF FILE CABINET.
KEEP ALL MUTATION SHEETS UNTIL END OF CLASS THURSDAY.