BELL WORK:         
What do you think of when you
​hear the word mutation?

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Essential Question:
What are the types of DNA mutations, and what effect
do they have on transcription/translation?

Instructional Focus / TLW:
Explain how DNA mutations modify proteins.














BEFORE WE MOVE ON....
​THINGS WE ALREADY KNOW THAT WILL HELP...
In DNA:  Replication
A-T-C-G 
T-A-G-C

DNA TO mRNA: Transcription
A-T-C-G        Use codon wheel.
U-A-G-C          RNA HAS "U" NOT "T"

mRNA TO tRNA:   Translation /polypeptide
U-A-G-C      
A-U-C-G
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MUTATION FACTS:
1. A mutation is a change that occurs in our DNA sequence.
2. Mutations can occur during DNA replication.
3. There are several types of DNA mutations.
4. DNA mutations may or may not cause a problem.















We will investigate several
types of DNA Mutations:
1. Point
2. Substitution
3. Inversion
4. Insertion / Frameshift
5. Deletion / Frameshift
* And later analyze for missense and nonsense mutations...
missense = a change in one amino acid in a protein
nonsense = codon is changed to a premature stop

 /








​Instructional Focus / TLW:
Explain how DNA mutations modify proteins.
1. Complete the POINT mutation handout. USE A CODON WHEEL.
We will compare lines 2, 3, 4, 5, 6, and 7 to line 1.
Line one is the "NORMAL" DNA.

​Instructional Focus / TLW:
Explain how DNA mutations modify proteins.
1. Complete the SUBSTITUTION mutation handout. USE A CODON WHEEL.
We will compare lines 2, 3, 4, 5, 6, and 7 to line 1.
Line one is the "NORMAL" DNA.

THE ONLY THING YOU TURN IN TODAY IS THE TICKET / QUIZ.
HIGH-QUALITY COMPLETE ANSWERS ARE EXPECTED.
TICKET / QUIZ:
1. List​ 3 things that you learned today.
2. Explain or draw: How to recognize a point mutation?
3. Explain or draw: How to recognize a substitution mutation?
4. Explain how DNA mutations modify proteins. 
TURN IN TICKET-QUIZ---GREEN CONTAINER-TOP OF FILE CABINET.

KEEP ALL MUTATION SHEETS UNTIL END OF CLASS THURSDAY.




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